Award details

Linking genetics and epidemiology: a structural approach to disease genetics

Reference	BBS/E/R/00000659
Principal Investigator / Supervisor	Professor Stephen Bishop
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	74,938
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2005
Duration	48 months

Abstract

Disease resistance traits pose a particular problem to geneticists as they contravene crucial asumptions made in quantitative genetic theory. In particular, animals are not independent of each other in their expressions of resistance and there is an interrelationship between host genotype for resistance and disease epidemiology. This impacts on decision-making processes in disease genetics. This project addresses these issues. The objectives are (i) to develop a general theoretical framework combining quantitative genetics and epidemiology theory, (ii) to develop strategic epidemiological models describing specific disease scenarios, including (a) nematode infections, (b) viral epidemics and (c) continuous challege infections, and (iii) to develop advanced genetic management strategies for these three disease scenarios.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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