Award details

Identification, comparison and analysis of factors that influence development of cloned mouse embryos

Reference	BBS/E/R/00000658
Principal Investigator / Supervisor	Professor Ian Wilmut
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	86,566
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2005
Duration	48 months

Abstract

Entirely new opportunities in medicine and biology are being created by the demonstration that mammalian cells and nuclii have a far wider developmental ability than previously understood. Understanding of the mechanisms that regulate developmental ability of the nucleus is required if full advantage is to be taken of these opportunities. This project will contibute knowledge by identifying factors that influence development of cloned mouse embryos and assessing them and analysing their mechanism by discovering if the effects are additive. In addition, this will provide the intellectual and technical framework for collaborative studies of their cellular and molecular basis. Factors to be analysed including a comparison of G0 and G1 phase of the cell cycle in donor cells of the same phenotype, serial transfer and a method of chemical enucleation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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