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Regulatory pathways controlling chondrogenesis and chondrocyte terminal differentiation during bone growth
Reference
BBS/E/R/00000657
Principal Investigator / Supervisor
Professor Colin Farquharson
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
166,264
Status
Completed
Type
Institute Project
Start date
01/06/2000
End date
31/03/2004
Duration
46 months
Abstract
The formation of the cartilaginous skeleton involves 2 key differentiation: chondrocyte formation from the committed mensenchymal precursor and terminal chondrocyte maturation. The present knowledge of the genes responsible for regulating chondrocyte differentiation leaves many questions unanswered and an improved understanding of the pathways involved will help us to understand more fully the genetic mechanisms that underpin normal bone growth and development. In this study we will clarify the role of known chondrocyte regulators and in addition will use the tools and resources associated with functional genomics to identify novel regulators of chondrocyte differentiation. These studies will provide fundamental information on bone formation and growth and will be relevant to farm animal breeding, productivity and welfare.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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