BBSRC Portfolio Analyser
Award details
Genetic control of immune responsiveness in cattle
Reference
BBS/E/R/00000647
Principal Investigator / Supervisor
Professor Elizabeth Glass
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
253,218
Status
Completed
Type
Institute Project
Start date
01/04/1999
End date
31/03/2004
Duration
60 months
Abstract
Polymorphism in the major histocompatibility complex (MHC) modulates immune responses through variable binding of antigenic peptides. We have developed a model system for MHC class II structure-function analysis using cattle characterised for distinct immune responses to a peptide antigen (FMDV15). The influence of MHC polymorphism on the T cell responses seen in these cattle will be analysed using transfectants and transgenic mice expressing cloned class II DR and DQ genes . In related projects we will be mapping the cattle MHC, and investigate variation in MHC polymorphism and immune response to vaccination in a large crossbred resource herd (RoBogen). These studies will allow the contribution of MHC and other loci to be evaluated in a relevant cattle population.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search