Award details

Signal transduction and transcriptional activation in diazotrophs

Reference	BBS/E/J/42004013
Principal Investigator / Supervisor	Professor Raymond Alan Dixon
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	90,423
Status	Completed
Type	Institute Project
Start date	01/01/2000
End date	31/03/2001
Duration	15 months

Abstract

Global responses to environmental stress require a pivotal link between signal transduction and transcription to control metabolic responses. In many cases this is a multifactorial process, involving complex signal transduction cascades in association with transcription factors, sigma factors and RNA polymerase. This project focuses on systems that respond to multiple environmental stresses in order to determine how signal transduction pathways are integrated to control activation of transcription at sigmaN (sigma54)-dependent promoters. These systems involve complex molecular machines which sense a number of different signals and couple the hydrolysis of ATP to transcription initiation by sigmaN several RNA polymerase holoenzyme. A multidisciplinary approach, incorporating cell physiology, biochemistry, molecular genetics and structural biology, is being used to analyse protein/protein, protein/ligand and protein DNA interactions in order to describe the detailed molecular mechanisms of transcriptional regulation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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