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Biomimetic metal-sulphur complex and cluster chemistry and spectroscopy

Reference	BBS/E/J/40004048
Principal Investigator / Supervisor	Professor David Evans
Co-Investigators / Co-Supervisors	Dr David Hughes
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	262,915
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Iron-sulphur clusters are ubiquitous in nature. Reactions catalysed by iron-sulphur clusters include the reduction of dinitrogen to ammonia (nitrogenases), the production and consumption of dihydrogen (e.g. NiFe-hydrogenase) and the conversion of citric acid to isocitric acid (aconitase in the TCA cycle). No appropriate functional synthetic analogues have been prepared. This work explores chemical routes to novel homo- and hetero-nuclear cluster systems which mimic the structure and function of the metal centres found in these, and other, metalloenzymes. The strategy is to: (a) construct clusters with appropriate structural features; (b) build cluster molecules which contain bound substrates, intermediates or products. The spectroscopic, especially Mossbauer and multinuclear NMR, and reactivity properties of new materials are examined. X-ray crystallography is used to define their structure. Refer to 4040, 4026

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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