Award details

Next generation disease resistance breeding in plants

Reference	BBS/E/J/000CA485
Principal Investigator / Supervisor	Professor Mark Banfield
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	167,724
Status	Current
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Plant diseases represent a significant threat to global food security. One of the most notorious plant pathogens is the Irish potato famine organism Phytophthora infestans. P. infestans, the causal agent of potato and tomato late blight, continues to cost modern agriculture billions of euros annually. As part of a large collaborative grant, this project will build on the identification of core set of effector proteins in P. infestans that are likely critical for pathogenicity. It also builds on the knowledge that plant proteins targeted by P. infestans effectors are important components of the immune response, and new insights into how effectors are recognised by plant Resistance proteins. Specifically, we aim to understand the molecular details of how three P. infestans effectors modulate plant immunity. To do this we will study how these three effectors associate with their plant targets. We will use protein/protein interaction assays, such as yeast-2-hybrid and co-immunoprecipitation (in planta), to define important regions for interaction and then interrogate the interactions in solution using recombinant proteins and a variety of biophysical approaches. We will determine the three-dimensional structures of the effectors, their identified plant targets and possibly the complexes. Finally, we will biochemically dissect effector-activated Resistance-protein immunity and ask to what extent are the plant effector targets important for this.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Crop Science, Microbiology, Plant Science, Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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