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Defining the symbiotic calcium channel of legumes

Reference	BBS/E/J/000CA482
Principal Investigator / Supervisor	Professor Giles Oldroyd
Co-Investigators / Co-Supervisors	Professor Dale Sanders
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	54,440
Status	Completed
Type	Institute Project
Start date	16/04/2012
End date	15/04/2015
Duration	36 months

Abstract

Nuclear associated oscillations in calcium sit at the core of the symbiosis signalling pathway, allowing the transduction of information from perception of microbial signalling molecules at the cell surface to gene expression changes in the nucleus. While genetic dissection has revealed many of the components involved in symbiosis signalling in legumes, the proteins directly responsible for the regulation of calcium levels have not been discovered. Using nuclear-targeting as a criteria we have identified a cyclic nucleotide gated (CNG) channel that is a strong candidate for the symbiotic calcium channel. In this proposal we will use a combination of molecular genetics and electrophysiological approaches to characterize the putative CNG complex responsible for symbiotic calcium signalling. The main objectives of this work are: 1. To ascertain the roles of the different nuclear-localised CNGs in nodulation and mycorrhization. 2. To define the CNG complex that resides on the nuclear envelope. 3. To define the selectivity and regulatory properties of the channel complex.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Microbiology, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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