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Award details
LAntibiotic Production: Technology, Optimization and improved Process
Reference
BBS/E/J/000CA423
Principal Investigator / Supervisor
Professor Mervyn Bibb
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
159,979
Status
Completed
Type
Institute Project
Start date
01/07/2010
End date
30/06/2013
Duration
36 months
Abstract
The aim of this project is to analyse the regulation of lantibiotic biosynthesis in actinomycetes. Lantibiotics are ribosomally synthesised peptide antibiotics that undergo a variety of post-translational modifications. The project will focus on NAI-107 (also known as microbisporicin) produced by Microbispora sp. The aim is to understand how the production of this compound is activated, and to dissect the roles, and relationships between, both pathway-specific and global regulatory genes. The interaction between lantibiotic biosynthesis and self-resistance will also be analysed.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Industrial Biotechnology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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