Award details

Silencing RNAs: organisers and coordinators of complexity in eukaryotic organisms (SIROCCO)

Reference	BBS/E/J/000CA305
Principal Investigator / Supervisor	Professor Dame Caroline Dean
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	528,030
Status	Completed
Type	Institute Project
Start date	01/01/2007
End date	30/09/2011
Duration	57 months

Abstract

The onset of flowering in Arabidopsis is controlled by a complex genetic network with many endogenous and environmental input pathways. FLC is a major repressor of flowering whose expression is repressed by endogenous and low-temperature signals. FLC is mis-regulated in mutants defective in RNA silencing, implicating both siRNA and miRNA involvement in FLC repression. The Dean lab contribution to SCIROCCO will systematically define all the RNA silencing pathways that regulate FLC throughout development and will define whether the RNA silencing components function in the known pathways involving RNA processing and chromatin regulation or in novel FLC regulatory pathways. Work will include detailed expression analysis of FLC fusions, epistasis analysis and molecular characterization of FLC sense and antisense transcripts and chromatin modifications.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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