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Biophysical analysis of fundamental microbial processes

Reference	BBS/E/J/000C0649
Principal Investigator / Supervisor	Professor David Lawson
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	389,926
Status	Completed
Type	Institute Project
Start date	01/04/2008
End date	31/05/2012
Duration	50 months

Abstract

Streptomycetes are soil dwelling bacteria capable of producing a wide range of potentially useful secondary metabolites including antibiotics. Their genomes contain a high proportion of regulatory genes. We are particularly interested in those that are predicted to be involved in ligand-mediated transcriptional control. This work will involve the analysis of knockout mutant phenotypes, and the identification of effector ligands and cognate DNA sequences towards dissecting a range of signalling pathways. The aminocoumarin antibiotics are potent inhibitors of the validated drug target DNA gyrase. We will study how these compounds are biosynthesised, how they interact with their target enzymes and how they are dealt with by resistance mechanisms.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Microbiology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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