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Award details
Development of real-time biosensors
Reference
BBS/E/J/000C0642
Principal Investigator / Supervisor
Professor Philip Poole
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
114,046
Status
Completed
Type
Institute Project
Start date
25/06/2007
End date
31/05/2012
Duration
60 months
Abstract
Bacteria are able to detect a large array of natural products that they can transport, degrade or modify. For example plant associated bacteria such as Rhizobium and Pseudomonas synthesise hundreds of specific ABC transport systems that are induced by a diverse array of sugars, amino acids, flavonoids and alkaloids. We are developing ABC solute binding proteins to produce FRET based biosensors that report the presence of their natural ligands. Metagenomic biosensor libraries of sequenced bacteria are also being screened for the detection of novel metabolic pathways involved in the modification and break down of natural products.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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