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Protein structure and dynamics - information processing

Reference	BBS/E/J/000C0640
Principal Investigator / Supervisor	Professor Richard Morris
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	211,488
Status	Completed
Type	Institute Project
Start date	05/01/2005
End date	31/03/2017
Duration	146 months

Abstract

The ability of proteins to recognise correct ligands in crowded environments is remarkable. To understand this process of molecular recognition we are investigating new mathematical ways of describing shape and shape complementarity. We have developed orthogonal polynomial based approaches for capturing 3D objects accurately and have devised a unique comparison metric for efficient shape matching. These techniques are being extending to include further properties within the same polynomial expansion. One practical application of these approaches is for ligand identification in crystallographic electron density maps which is being investigated in collaboration with Dr Dave Lawson from Biological Chemistry. A second strand of research in this area is investigating information processing properties of systems of proteins rather than individual protein-ligand interactions in isolation, i.e. the interplay of different molecular recognition processes. This work is being carried out in collaboration with Prof Ray Dixon, who is interested in the way bacteria have developed the ability to respond to a multitude of environmental signals and integrate these signals to trigger adaptive responses. We are modeling protein interactions and signal transduction in full kinetic simulations in order to shed light on the molecular mechanisms by which these signals are perceived and integrated.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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