Award details

Mathematical modelling in developmental and cell biology

Reference	BBS/E/J/000C0637
Principal Investigator / Supervisor	Professor Martin Howard
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	785,579
Status	Completed
Type	Institute Project
Start date	01/07/2007
End date	31/03/2017
Duration	116 months

Abstract

This project aims to understand through mathematical modelling the fundamental mechanisms used by cells to make precise decisions in space and in time. Specific topics include the epigenetic dynamics of vernalization in Arabidopsis, the precision of positional information provided by noisy morphogen gradients in Drosophila, modelling membrane deformation in the early stages of phagocytic cup formation, uncovering the dynamics of PAR protein polarity in C. elegans, and modelling cell cycle signal transduction/amplification in the spindle assembly checkpoint. Techniques used include ordinary/partial differential equation models, often in the form of reaction-diffusion equations, as well as Langevin equations. Stochastic simulations are frequently employed, typically using Monte-Carlo methods. Close collaboration with experimental groups both at the John Innes Centre and elsewhere is a key element of our approach.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Plant Science, Systems Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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