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Stem cell activity in Arabidopsis (STAR)

Reference	BBS/E/J/0000A196
Principal Investigator / Supervisor	Professor Robert Sablowski
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	35,445
Status	Completed
Type	Institute Project
Start date	01/09/2004
End date	31/08/2006
Duration	24 months

Abstract

Functional analysis of Arabidopsis genes that may participate in conserved stem cell functions. In animal and plant development, stem cells give rise to a variety of differentiated cells and perpetuate their own undifferentiated lineage. Cell division regulators are expected to be active in stem cells. Much less is known about what genes maintain a pluripotent state. A set of 300 genes preferentially expressed in mouse stem cells has been published. We have identified 290 genes preferentially expressed in Arabidopsis meristems (where stem cells reside). Comparison of both sets reveals 22 conserved genes, including 12 known cell cycle regulators and at least one gene (PKL, encoding a chromodomain protein) that controls embryonic identity in Arabidopsis with no known link to cell division control. We aim to test whether 9 of the conserved genes are required for stem cell functions in Arabidopsis. These genes may participate in a core of stem cell functions conserved in animals and plants.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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