Award details

New insights into bacterial outer membrane biosynthesis

Reference	BBS/E/J/0000A090
Principal Investigator / Supervisor	Professor Tracy Palmer
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	52,690
Status	Completed
Type	Institute Project
Start date	01/07/2002
End date	01/07/2005
Duration	36 months

Abstract

Strains of Escherichia coli deleted for the Tat protein export pathway show pleiotropic defects in their outer membrane. This phenotype is not due to the mislocalisation of any previously identified Tat substrate protein. This proposal has the following specific objectives: (i) to identify the specific outer membrane defect in the tat mutant strains; (ii) to assess whether the Tat system plays a direct role in outer membrane biogenesis by exporting a critical protein involved in the biogenesis process (iii) to characterise the physiological function of the novel and highly conserved YjeE protein; and (iv) to map further mutations that genetically suppress the outer membrane defect of tat mutants.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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