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A novel signal transduction system for Ammonium
Reference
BBS/E/J/0000A078
Principal Investigator / Supervisor
Professor Mike Merrick
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
52,492
Status
Completed
Type
Institute Project
Start date
30/09/2002
End date
29/09/2005
Duration
36 months
Abstract
In nearly all bacteria and archaea for which genome sequences are presently available the genes encoding the ammonium transporter AmtB and the signal transduction protein GlnK are linked. We have recently demonstrated that this linkage reflects the fact that GlnK is sequestered to the cell membrane in an AmtB-dependent manner. We propose that these two proteins constitute a novel and ubiquitous signal transduction pathway that not only provides a sensitive mechanism of regulating ammonium transport activity but also couples the activity of the transporter, and thereby a measure of the extracellular ammonium concentration, to an intracellular signal transduction protein. The object of this proposal is to dissect the structural, mechanistic and physiological details of this newly discovered signal transduction system.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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