Award details

Cell division control and virulence in mycobacteria

Reference	BBS/E/J/0000A071
Principal Investigator / Supervisor	Professor Keith Chater
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	135,265
Status	Completed
Type	Institute Project
Start date	01/09/2001
End date	30/06/2006
Duration	58 months

Abstract

This project is funded by the US NIH. Its central aim is to analyse the structure and function of the WhiB protein, which plays different, but key, roles in antibiotic-producing streptomycetes and disease-causing (tuberculosis, leprosy etc) mycobacteria, and is a promising target for therapeutic agents. JIC focuses on WhiB and related proteins in Streptomyces, while the main grantholder (Johns Hopkins University, Baltimore) works on mycobacteria. We have shown that these proteins sense changes in the oxidative state of the cell, and have found that two members of the WhiB family affect the interplay of Streptomyces colony differentiation and antibiotic production. Our results are providing pointers for parallel work on the tuberculosis organism, which is much harder to work on experimentally.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search