Award details

3D analysis of transgene integration and expression in wheat

Reference	BBS/E/J/0000A002
Principal Investigator / Supervisor	Professor Peter Shaw
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	113,313
Status	Completed
Type	Institute Project
Start date	02/07/2001
End date	01/07/2004
Duration	36 months

Abstract

We have recently shown that multiple transgenes integrated into the wheat genome can be separated by large regions (several Mb) of genomic sequence, or can even be on opposite chromosome arms. However, in interphase these multiple sites are generally recruited to or organized at a single site in the interphase chromosome territories. This proposal is aimed at understanding the mechanism underlying the interphase organization; does it reflect a highly conserved interphase chromosome architecture, or is it the result of incorporating novel transgenes and associated sequences into the genome? Such ectopic interactions between multiple transgenes have implications for gene expression, transcriptional silencing, and meiotic homologue pairing.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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