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Sensing and responding to nitrogen and oxygen stress through NIFL:NIFA two-component regulatory system
Reference
BBS/E/J/00004202
Principal Investigator / Supervisor
Professor Raymond Alan Dixon
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
72,457
Status
Completed
Type
Institute Project
Start date
03/04/2000
End date
18/08/2003
Duration
41 months
Abstract
The expression of bacterial operons encoding proteins required for nitrogen fixation is controlled at the level of transcription initiation in response to the level of fixed nitrogen, environmental oxygen and potentially the energy status. We intend to use a combination of physiological, biochemical and genetic approaches to understand how these stresses are perceived and integrated by the anti-activator NIFL and transduced to the transcriptional activator NIFA to control biosynthesis of a highly expressed bacterial protein under stringent conditions. This will provide a paradigm for understanding how protein complexes interact with intracellular signals to bring about changes in gene expression under conditions of nutrient limitation and may lead to the design of novel expression vectors.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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