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The structural biology of cell signalling in animals, plant and microbes
Reference
BBS/E/J/00004201
Principal Investigator / Supervisor
Professor Raymond Alan Dixon
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
143,322
Status
Completed
Type
Institute Project
Start date
29/11/1999
End date
28/03/2005
Duration
64 months
Abstract
The objective is to study the structural biology of signalling, including receptor activation at the cell surface, and signal transduction in the cytoplasm, leading to control of transcription. These processes involve multicomponent complexes, some of which are stable and other transient. We will study the structures of microbial, plant and mammalian systems, with a view to comparative analyses. We propose the establishment of linked laboratories in microbial, animal and plant protein expression and preparation, nuclear magnetic resonance, protein crystallography, mass spectroscopy, microcalorimetry and computing, exploiting strengths and bringing to critical mass expertise in structural and cell biology at Cambridge University, University of East Anglia, John Innes Centre and Babraham Institute.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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