Award details

Environmental signal transduction in microbes

Reference	BBS/E/J/00004010
Principal Investigator / Supervisor	Professor Mike Merrick
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	607,856
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Characterisation of the involvement of nitrogenase function in nif expression by measurements of gene expression, and protein production during nitrogenase synthesis. The ability to perceive and to respond to environmental stress is vital to all forms of life. Consequently, organisms have evolved specialised signal transduction pathways which permit adaptation to a multitude of environmental signals. Through these pathways the organism is able to coordinate gene expression and metabolism, which ultimately determine the physiology of a cell. Due to their relative simplicity, prokaryotic systems have provided excellent models for detailed analysis of the molecular mechanisms underlying signal transduction processes. This project aims to understand how bacteria sense fluctuations in the status of three key growth-limiting factors, namely oxygen, nitrogen and carbon, and the means by which they adapt optimally to these fluctuations. A multidisciplinary approach comprising biochemistry, physiology, structural and molecular biology is being employed to understand, at the molecular level, the communication of environmental signals with cellular metabolic processes.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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