Award details

Multifactorial transcriptional control in prokaryotes

Reference	BBS/E/J/00004009
Principal Investigator / Supervisor	Professor Raymond Alan Dixon
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	560,212
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Transcriptional control is the pivotal link between signal transduction processes and metabolic responses. In many cases this is a multifactorial process, involving interactions between activator or repressor proteins, nucleoid-associated proteins, sigma factors and RNA polymerase. The project focuses on a number of systems that respond to multiple environmental stresses in order to determine how signal transduction pathways are integrated at the level of transcription. Some of these systems display long range transcriptional activation and coupling of ATP hydrolysis to transcription initiation., properties also characteristic of eukaryotic gene control. A multidisciplinary approach, incorporating cell physiology, biochemistry, molecular genetics and structural biology, is being used to analyse protein/protein and protein/DNA interactions in order to describe the detailed molecular mechanisms of gene transcription.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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