Award details

Expression of animal virus antigens in plants using viral vectors

Reference	BBS/E/J/00001407
Principal Investigator / Supervisor	Professor George Lomonossoff
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	78,074
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/10/1999
Duration	31 months

Abstract

To overcome the problems associated with the large- scale production of immunologically active complexes, methods for their expression in plants will be developed. Autonomously replicationg virus- based vectors will be used to express the proteins of interest. Such vectors offer a convenient route for the expression of high levels of antigens in plants. Immune protection against coronaviruses is mediated by the spike (S) protein. The protection induced by the full-length S protein, or selected antigenic domains thereof, coupled to carrier molecules for tissue-specific targeting, expressed in plants using recombinant viruses will be determined. Extracts from plants expressing immuno- complexes will be used for the oral immunisation of experimental animals, thereby targeting the antigens to the gut-associated lymphoid tissue (GALT) in order to induce protective mucosal immunity.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search