BBSRC Portfolio Analyser
Award details
Metabolic engineering of Streptomyces for improved production of bioactive molecules
Reference
BBS/E/J/00001240
Principal Investigator / Supervisor
Professor Keith Chater
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
65,671
Status
Completed
Type
Institute Project
Start date
01/04/2001
End date
01/04/2004
Duration
36 months
Abstract
The project seeks to apply metabolic engineering to improve the production of bioactive compounds in model streptomycetes that are used in industry as hosts for the production of novel metabolites. We have identified two distinct mechanisms for increasing antibiotic yeild in fermentations of Steptomyces lividans. We wish to determine whether these alterations are additive when used in combination. The effects of these and other genetic modifications will be assessed using Metabolic Flux and Elementary Modes Analyses. Information derived from the Streptomyces coelicolor genome sequence and its functional analysis will identify additional targets for manipulation that should further enhance the efficiency of bioactive molecule production.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search