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Quorum-sensing control of stationary phase adaptation and associated resistance to environmental stresses in Rhizobium leguminosarum
Reference
BBS/E/J/00001230
Principal Investigator / Supervisor
Professor J Downie
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
60,125
Status
Completed
Type
Institute Project
Start date
10/07/2000
End date
27/10/2003
Duration
40 months
Abstract
The aim of this study is to dissect out the molecular mechanisms involved in multiple traits including adaptation to stationary phase by Rhizobium leguminosarum and the associated acquired resistance to multiple environmental stresses. The response mechanism is regulated by a cascade of four quorum-sensing regulons that produce multiple N-acyl homoserine lactones (AHLs). Characters regulated by this system include: stationary phase adaptation and survival; resistance to salt and several other stresses, and rhisosphere growth and legume nodulation. Using mutants defective for AHL production, genes induced by AHLs will be identified from a promoter library fused to gfp. The identified genes will be characterised in detail and their role in adaption to stress determined both in vitro and in association with legume roots.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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