Award details

Making the most of a genome sequence

ReferenceBBS/E/J/00001227
Principal Investigator / Supervisor Professor Keith Chater
Co-Investigators /
Co-Supervisors
Institution John Innes Centre
DepartmentJohn Innes Centre Department
Funding typeResearch
Value (£) 135,529
StatusCompleted
TypeInstitute Project
Start date 01/11/1999
End date 31/10/2002
Duration36 months

Abstract

(i) Using PCR primers designed from the emerging Streptomyces coelicolor A3(2) genome sequence, whole-genome gene arrays will be produced, made available to the community, and their use (in terms of linearity and specificity) validated for the analysis of the transcriptome; (ii) a proteome map of the organism will be produced and validated; (iii) a suite of bioinformatic tools will be developed and made available for extracting biologically meaningful data from the proteome and transcriptome, which will be linked to the annotated genome database being produced at the Sanger Centre. (iv) the transcriptome and proteome of a variety of mutant strains will be analysed and of the wild type during the transition to methylenomycin production in batch culture and during sporulation.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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