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Extracellular signals for antibiotic production in Streptomyces coelicolor

Reference	BBS/E/J/00001220
Principal Investigator / Supervisor	Professor Mervyn Bibb
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	25,391
Status	Completed
Type	Institute Project
Start date	02/02/1998
End date	01/01/2001
Duration	35 months

Abstract

Type B antibiotics are small peptides containing modified amino acids that exhibit a range of interesting properties that could lead to their development as important new pharmaceutical agents. However they exist in only a few natural forms. We intend to exploit their biosynthetic genes to produce a range of new structures. The genes for production of the "Type B" antibiotic cinnamycin made by Streptomyces longisporoflavus will be cloned and genetically manipulated to produce novel compounds in the industrially-favoured Streptomyces lividans. The regulation of cinnamycin production will be studied in S. lonisporoflavus and the genetically-well studied Streptomyces coelicolor, allowing knowledge-based approaches to yield improvement.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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