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The molecular biology and molecular pathology of cereal geminiviruses and legume tobraviruses and their interactions with plants

ReferenceBBS/E/J/00000162
Principal Investigator / Supervisor Professor J Davies
Co-Investigators /
Co-Supervisors
Institution John Innes Centre
DepartmentJohn Innes Centre Department
Funding typeResearch
Value (£) 499,260
StatusCompleted
TypeInstitute Project
Start date 01/04/1997
End date 31/03/2001
Duration48 months

Abstract

This project is an investigaion of: 1. The gene expression, gene functions and replication of monopartite DNA genome geminiviruses, in particular maize strak virus (MSV). Genetic manipulation, mutagenesis, single cell and whole plant analysis are used to study promoter activity and specificity, enhancers, splicing and transactivation mechanisms. Mutants and structural analyses are used to investigate the role of the coat protein (CP) in symptom expression, assembly and virus movement including nuclear localisation. The movement function(s) of the pre-coat gene V1 product, the movement protein (MP) its interactions with host components, CP, and DNA are studied by genetic, structural and cell biological techniques. The objectives are to understand protein - protein and virus-plant interactions involved in host specificity, cell-to-cell and long distance movement, and symptom development, and to derive new approaches to disease control. 2. The molecular biology of the RNA tobravirus pea early browning virus (PEBV), and application of the fundamental knowledge of its genes to understanding the molecular pathology of the disease and its virus- plant interactions. This includes characterisation of a gene for seed transmission of PEBV and RNA - mediated resistance phenomena, co-suppression and gene silencing in transgenic - plants.

Summary

unavailable
Committee Closed Committee - Plant & Microbial Sciences (PMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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