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Molecular mechanisms of signal transduction and transcriptional activation in bacteria

Reference	BBS/E/J/00000016
Principal Investigator / Supervisor	Professor Raymond Alan Dixon
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	2,081,453
Status	Completed
Type	Institute Project
Start date	01/01/2000
End date	31/03/2017
Duration	206 months

Abstract

Global responses to environmental stress require a pivotal link between signal transduction and transcription to control metabolic responses. In many cases this is a multifactorial process, involving complex signal transduction cascades in association with transcription factors, sigma factors and RNA polymerase. This project focuses on systems that respond to multiple environmental stresses in order to determine how signal transduction pathways are integrated to control activation of transcription at sigma54-dependent promoters. Transcriptional regulation in such systems involves complex molecular machines that sense a number of different signals and couple the hydrolysis of ATP to transcription initiation by sigma54–RNA polymerase holoenzyme. A multidisciplinary approach, incorporating cell physiology, biochemistry, molecular genetics and structural biology, is being used to analyse protein-protein, protein-ligand and protein DNA interactions in order to characterise molecular mechanisms of transcriptional regulation in various bacterial species. Mechanistic studies of these systems may ultimately provide important targets for chemotherapeutic intervention or exploitation.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Microbiology, Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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