Award details

Understanding the basis for morphological differentiation and antibiotic production in Streptomyces

Reference	BBS/E/J/00000011
Principal Investigator / Supervisor	Professor Keith Chater
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	1,625,161
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	23/04/2004
Duration	84 months

Abstract

Streptomyces coelicolor (A3(2) is, through our pioneering work, genetically the most studied member of the genus world-wide and is becoming the paradigm for the actinomycetes. We are studying and using its genetics to understand Streptomyces as a complex, differentiating prokaryotic genetic system as well as for the applied goals mentioned in the PU description. We aim to characterise its genome and accessory genetic elements physically, where possible at the DNA sequence level and to develop the existing gene tool-kit further. We will study the extracellular and intracellular signals that trigger the alternative stationary phase fates of morphological differentiation (aerial growth and sporulation) and secondary metabolism (antibiotic production) and the signal transduction cascades that bring about expression of the relevant genes. This will also involve studies of the basic gene expression apparatus (especially RNA polymerase sigma factors). The molecular basis of the programming of polyketide synthesis to give specific end products will be pursued. We will investigate the basis of sporulation-associated processes such as cell division and glycogen and pigment synthesis. Via collaborations, we will explore the relevance of knowledge about Streptomyces to the investigation of pathogenic mycobacteria.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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