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Identification of essential host proteins for the control of nidovirus replication

Reference	BBS/E/I/00002535
Principal Investigator / Supervisor	Dr Helena Maier
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	90,752
Status	Completed
Type	Institute Project
Start date	01/01/2016
End date	31/03/2017
Duration	14 months

Abstract

The aim of my research is to “identify essential host proteins for the control of nidovirus replication” using avian coronavirus, infectious bronchitis virus (IBV), as a model, and making comparisons initially to porcine and human coronaviruses and more distantly related nidovirus, porcine reproductive and respiratory syndrome virus. More diverse positive sense RNA (+RNA) viruses will be incorporated in the future through collaboration with other groups at TPI. By adopting a comparative virology and “One Health” approach to understand key conserved steps in virus replication, development of pan-virus control measures may be possible. The virus lifecycle can be simply divided into three stages – entry, replication and exit. Although entry varies between nido- and coronaviruses, virus induction of cellular membrane rearrangements during replication and virus budding to gain a lipid envelope during exit are conserved steps. Using cell biology, ‘omics and new bioimaging technologies, fundamental understanding of virus replication and interactions between the virus and host with a particular emphasis on host factors will be achieved. Subsequently, potential to control virus replication through altering virus-host interactions will be investigated. The programme consists of three work areas.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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