Award details

Fellowship in Vaccinology

Reference	BBS/E/I/00002067
Principal Investigator / Supervisor	Dr Efrain Guzman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	266,528
Status	Completed
Type	Institute Project
Start date	01/01/2015
End date	31/03/2017
Duration	26 months

Abstract

Vaccination is said to be one of our society’s greater achievements. Through vaccination, diseases such as smallpox in humans and rindepest in livestock have been eradicated and are no longer a burden to society. However, most vaccines used today were developed empirically through trial and error during the first half of the 20th century, and we are just now beginning to understand mechanisms of protection. On one hand, dendritic cells (DC) are central to the development and maintenance of immune responses priming and maintaining T cell responses. On the other hand, tolerogenic DC (tDC) induce the proliferation and maintenance of regulatory cells, which in turn maintain immunological homeostasis. The understanding of DC biology, plasticity and function underpins the development of novel and improved vaccines in both animals and humans. I propose to establish a research programme to study the components of the bovine immune system in the context of infection and vaccination with dendritic cells as the focus of interest.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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