Award details

Studentship: Investigation into the effect of spike glycoprotein glycosylation for rational vaccine development

Reference	BBS/E/I/00001977
Principal Investigator / Supervisor	Dr Erica Bickerton
Co-Investigators / Co-Supervisors	Professor Paul Britton
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	60,317
Status	Completed
Type	Institute Project
Start date	01/02/2014
End date	31/03/2017
Duration	37 months

Abstract

Infectious bronchitis virus (IBV) has four structural proteins; spike (S) glycoprotein, membrane (M) and envelope (E) proteins which are found in the lipid membrane surrounding the virus particle and the nucleocapsid (N) protein binds the positive-sense RNA genome. The S glycoprotein is highly glycosylated with N-linked high-mannose type oligosaccharides (Cavanagh et al., 1983) and mediates attachment of the virus to host cells and fusion of virus-cell and cell-cell. Previous work has shown that exchanging the spike of a strain of IBV for that from another strain can change the tropism of the recombinant virus.We wish to investigate the role of glycosylation of the S glycoprotein on infectivity and tropism of IBV for different cell types, both in vitro and in ovo for the development of novel vaccines.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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