Award details

Evaluation of antigen specific cell-mediated responses against viral infrections in chickens

Reference	BBS/E/I/00001825
Principal Investigator / Supervisor	Dr Shahriar Behboudi
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	902,878
Status	Completed
Type	Institute Project
Start date	01/03/2013
End date	31/03/2017
Duration	48 months

Abstract

T cell responses may be an important contributing factor in genetic resistance to viral infections such as MDV, perhaps by preventing reactivation of MDV from the latent phase in resistant and not in susceptible chickens. We hypothesize that cytotoxic CD8+ T lymphocytes (CTL) and CD4 T cells (T helper cells) are induced in the course of viral infections and T cell responses are targeted towards infected host cells that express viral antigens. The proposed research project investigates host-pathogen interactions, particularly T cell-mediated immune response to viruses including MDV in chickens. In this project, we aim to identify T cell epitopes within MDV-encoded proteins and analyse the functional abilities of these MDV specific T cells. Moreover, we will assess whether viral infection expands regulatory cells in chickens and thus suppress anti-virus immune responses. In brief, the results from this proposal will provide tools to develop vaccine formulations targeting CD4 and CD8 T cells recognizing the viral antigens that induce a protective immunity against MDV.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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