Award details

Explore the impact of genetic variation on the livestock immune response to pathogens

Reference	BBS/E/I/00001710
Principal Investigator / Supervisor	Professor John Hammond
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,055,737
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

This project aims to advance our understanding of the functional impact of genetic variation on the immune response of livestock, with particular emphasis on innate immune responses. The knowledge gained will enable a more accurate assessment of the interplay between different arms of the immune system through their effector cells during infection and vaccination. Advances in sequencing technology and analysis now provide the opportunity decipher genetic variation at the level of the genome and transcriptome at high resolution. These data facilitate the interrogation of specific immune components in vitro and in vivo to resolve their function and importance during particular pathogen infections. This project will use these methods to provide a basis for identifying gene variants that are beneficial or detrimental to the host during infection, a greater understanding of the molecular mechanisms that govern the immune response and better define potential correlates of protection.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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