Award details

Host resistance mechanisms to bovine respiratory syncytial virus (BRSV), African swine fever virus (ASFV) and Bluetongue virus (BTV)

Reference	BBS/E/I/00001709
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,222,492
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

The aim of this project is to advance understanding of the mechanisms of immunity to and the pathogenesis of African swine fever virus (ASFV), bluetongue virus (BTV) and bovine respiratory syncytial virus (BRSV). The knowledge gained will contribute to the development of new or improved vaccines. Developments in DNA technology have created new opportunities for vaccine production, both through genetic manipulation of pathogens and by enabling the identification of defined antigens that induce protective immune responses. These opportunities, together with a detailed understanding of the components of the immune response that mediate protection or which contribute to the pathogenesis of disease, and knowledge of how these responses can be induced and regulated at an appropriate location in vivo, will provide a conceptual framework for the rational development of new or improved vaccines against BRSV, ASFV and BTV.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology, Synthetic Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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