Award details

Determinants of transmission, adaptation and pathogenicity of avian influenza

Reference	BBS/E/I/00001708
Principal Investigator / Supervisor	Professor Munir Iqbal
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,085,932
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

The aim of the project is to identify molecular factors that enable avian influenza (AI) viruses to establish and cause sustained infections in poultry. This project will take forward our recent studies on evolution, adaption and transmission of AI viruses mainly focusing on the analysis of the diversity of AI viruses affecting poultry and identification of genetic correlates that facilitate the sustained infection in chickens and turkeys through gaining greater transmissibility and virulence. The identified evolutionary and host-specific adaptive changes will be used to construct mutant AI viruses and their potential effects on host tropism, infectivity, replication, transmission and virulence will be assessed in different host-origin tissue culture systems and animal models including chickens, turkeys and ducks. These studies will provide foundation for the improvement of avian influenza virus control strategies by developing new advanced efficacious vaccines and highly effective diagnostic tools enabling to minimise their impact on animals, public health and world economy.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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