Award details

Differentiation of Infection in Vaccinated Animals for PPR and FMD

Reference	BBS/E/I/00001703
Principal Investigator / Supervisor	Professor Satya Parida
Co-Investigators / Co-Supervisors	Dr Geraldine Taylor
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	429,696
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Peste des petits ruminants (PPR) is an acute, highly contagious viral disease in sheep and goats. South Asia, Middle East including Turkey and African countries including Morocco are endemic for PPR. The main strategy for disease control is vaccinating sheep and goats with live attenuated PPRV. However there are no DIVA vaccines currently available, preventing the differentiation of infection in vaccinated animals (DIVA) and seromonitoring. FMD is another acute and infectious disease of cloven-hoofed domestic animals for which DIVA vaccines would be of value. Recently we have developed two viral vectored based recombinant FMD DIVA candidate vaccines and the immunogenicity of these vaccines needs to be determined.As wild-type PPRV induces immunosuppression in sheep and goats, we need to determine if the live attenuated PPRV vaccine also induces immunosuppression as this could be a problem if PPRV is used as a vector to deliver multivalent vaccines, or if it is administered with other vaccines. If the vaccine strain does induce transient immunosuppression, further studies are needed to increase understanding of the mechanism of immunosuppression &/or to analyse the immunosuppressive effects.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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