Award details

RNA virus Evolution

Reference	BBS/E/I/00001653
Principal Investigator / Supervisor	Dr Donald King
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	366,867
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2014
Duration	24 months

Abstract

RNA viruses are genetically very diverse. They quickly emerge and evolve with high mutation rates, large population sizes, and short generation times. This fellowship aims to increase understanding of genetic and phenotypic characteristics that impact upon RNA virus evolvability. Focusing in the first instance on Foot-and-mouth disease virus, the project will investigate the limits of genetic variability at a consensus level. The evolution of the consensus sequence shall also be investigated using the power of next generation sequencing technologies. Complementary to this, in vitro experiments will be undertaken in order to understand how genetic diversity is generated within a cell, and how this impacts upon virus fitness.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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