Award details

Virus-host interactions of peste des petits ruminants virus (PPRV)

Reference	BBS/E/I/00001652
Principal Investigator / Supervisor	Dr Michael Baron
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	364,188
Status	Completed
Type	Institute Project
Start date	16/01/2012
End date	17/05/2013
Duration	16 months

Abstract

Peste des petits ruminants virus (PPRV) causes a significant disease in sheep and goats, the mainstay of subsistence farming in the developing world. PPRV has spread rapidly in the last twenty years and is now found from Morocco to China and from Turkey to Ethiopia. Its continued presence in the developing world and its devastating impact on the poorest farmers has strengthened the calls for a concerted eradication campaign. However little is still known about this virus highlighting the need for continued and focused investigation. The aim of the PPRV research fellowship at the IAH is to develop a fundamental understanding of the interactions that take place between this pathogen and its host during infection. Using techniques such as affinity tag purification to identify cellular factors and complexes involved in viral replication will provide detailed information about this economically significant disease of sheep and goats. In addition developing a better molecular understanding of PPRV will provide important and relevant information about pathogenesis, viral tropism and methods of rational attenuation. We are also developing the tools to undertake more wide-scale systems biology based analysis of PPRV infection.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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