Award details

Pre-clinical development of a simian adenovirus vectored respiratory syncytial virus (RSV) vaccine

Reference	BBS/E/I/00001632
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	73,315
Status	Current
Type	Institute Project
Start date	01/08/2012
End date	31/07/2015
Duration	36 months

Abstract

There is no commercial vaccine against RSV, a major cause of respiratory disease in infants and the elderly. A safe and effective RSV vaccine is needed that will not only protect young children, but which will also boost immunity in the elderly. We have constructed several AdCh/RSV vaccine candidates expressing RSV F, N and M2-1 proteins, which induce complete protection against RSV infection in BALB/c mice and cotton rats, either alone or in a heterologous prime/boost vaccine strategy with MVA/RSV. Importantly, intranasal vaccination did not prime for enhanced pulmonary pathology in either mice or cotton rats, following RSV challenge. However, a transient weight loss was observed in mice. Given the history of RSV vaccine-augmented disease in infants, further studies including ones in a more relevant animal model are required prior to embarking on clinical trials. The primary objectives of the project are to: (i) optimise and further evaluate AdCh/RSV vaccine candidates and the AdCh-RSV/MVA-RSV in mice and cotton rats (ii) evaluate the protective efficacy of the novel AdCh/RSV vaccine in calves, a natural infection model of RSV (iii) generate pre-GMP material for a rapid implementation of clinical development

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Immunology, Microbiology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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