Award details

Defining protective immune responses in livestock

Reference	BBS/E/I/00001615
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	33,837
Status	Completed
Type	Institute Project
Start date	05/04/2011
End date	04/04/2013
Duration	24 months

Abstract

Using mouse and livestock models of viral infection, improved assays will be developed to measure correlates of protection in cattle and pigs. In addition, we will investigate the importance of long-term retention of antigen in germinal centres of lymphoid tissue after infection, in the maintenance of a high titre serological response. The duration of circulating neutralising antibody titres and T cell responses will be measured following infection or immunisation with antigens in different formulations and of different physical characteristics. Specifically, improved assays will be developed to measure the specificity CD4 and CD8 responses in the circulation and at mucosal surfaces.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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