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Virus-host molecular interactions
Reference
BBS/E/I/00001595
Principal Investigator / Supervisor
Professor Paul Britton
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
111,635
Status
Completed
Type
Institute Project
Start date
01/01/2011
End date
30/09/2012
Duration
21 months
Abstract
The project aims to examine the virus-host molecular interactions using infectious bronchitis virus (IBV) as a model. Based on the observations that IBV replication is associated with membrane rearrangements leading to the generation of double membrane vesicles resembling autophagosomes, the current project will examine the cellular/subcellular localisation of viral proteins using recombinant tagged viruses and specific markers of autophagy such as LC3. The project will also examine the role of LC3 as a host factor in IBV replication using approaches such as RNAi.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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