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Phylogeography, transmission dynamics and pathogenesis of bluetongue

Reference	BBS/E/I/00001560
Principal Investigator / Supervisor	Professor Peter Mertens
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,800
Status	Current
Type	Institute Project
Start date	01/10/2010
End date	30/09/2015
Duration	60 months

Abstract

In this ambitious programme, we have assembled a group of researchers with complementary expertise in the biology of bluetongue, molecular virology, virus pathogenesis, virus genomics, virus ecology, mathematical modelling and metereology in order to provide a multifaceted and holistic approach to understanding key aspects of BTV biology, transmission dynamics and pathogenesis. In preparation for this programme, we have established a high throughput BTV sequencing pipeline involving the Wellcome Trust Sanger Institute and we will make use of the extensive BTV sample collection kept at IAH and in the Institutions of our collaborators (more than 1000 virus isolates and 4000 blood samples). We have quickly adopted the reverse genetics technology recently described by Boyce et al (10) for BTV that will allow us to genetically manipulate this virus and link genetic variation to specific virus phenotypes. Thus, collectively, we now have the expertise, technology, facilities and enthusiasm to embark on this timely research programme.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology, Systems Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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