Award details

BBSRC-funded studentship: The role of African swine fever virus membrane proteins in virus replication and immunomodulation

Reference	BBS/E/I/00001521
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors	Dr Haru - Hisa Takamatsu
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	18,659
Status	Completed
Type	Institute Project
Start date	27/09/2010
End date	26/09/2014
Duration	48 months

Abstract

Studentship. African swine fever virus is a large cytoplasmic DNA virus which encodes many proteins involved in evading the host's defence systems. This project will focus on one class of these proteins which are transmembrane proteins and are therefore predicted to be present on the surface of virus-infected cells. Interaction of the extracellular domain of these proteins with ligands on the surface or secreted from cells provides a mechanism for virus immunomodulation. The project will investigate the function of three ASFV membrane proteins by studying their localisation in cells, identifying ligands that they interact with and the functional consequences of these interactions. The information will be useful for the design of rationally attenuated African swine fever virus vaccines.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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