Award details

Structurally modified master seed viruses to enhance conventional foot-and-mouth disease virus vaccine protection

Reference	BBS/E/I/00001494
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	35,100
Status	Completed
Type	Institute Project
Start date	01/04/2010
End date	31/03/2013
Duration	36 months

Abstract

The current FMD vaccines are inactivated whole virus preparations. Despite success in the developed world, two major problems limit their capacity to control infections in developing countries. First, the virus is notoriously unstable, especially for the serotypes O and SAT2. During production the manufacturer has to compensate for this instability, which is expensive and reduces vaccine yield. Also, unstable vaccines are believed to be less immunogenic due to degradation before and after inoculation. In addition, to be effective, FMDV vaccines require frequent booster vaccinations, possibly due to vaccine antigen instability. Secondly, FMDV serotypes can be highly variable, especially serotypes A and SAT2, necessitating frequent development of new vaccine strains. Some viruses have proven very difficult to adapt to cell culture, slowing the manufacturing process, reducing vaccine yield and potentiating the selection of undesired antigenic changes.The main objectives of this proposal are to use reverse genetics to produce and market, on an industrial scale, recombinant FMD viruses with enhanced thermal stability and cell-culture growth. Currently, live recombinant viruses can be recovered and inactivated vaccine produced in the conventional manner. However, the feasibility of applying this technology on an industrial scale has not yet been tested.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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