Award details

Improving the quality of FMD vaccines by understanding the correlation of vaccine-induced protection with immune responses in cattle

Reference	BBS/E/I/00001489
Principal Investigator / Supervisor	Professor Satya Parida
Co-Investigators / Co-Supervisors	Dr Madhuchhanda Mahapatra, Professor David Paton, Dr Geraldine Taylor
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	428,720
Status	Completed
Type	Institute Project
Start date	17/05/2011
End date	16/05/2014
Duration	36 months

Abstract

The scientific hypotheses underlying our research are, firstly, that viral antigenic phenotype can be predicted from capsid gene sequences; and secondly that there is a measurable T cell component to vaccine-induced protection and that strengthening this would improve efficacy and duration of immunity. Our specific objectives are: (1) To define viral determinants of antigenicity and improve the selection of vaccine strains, particularly in Africa where there is the widest diversity of circulating viruses and few tailor-made vaccine strains. (2) To evaluate novel adjuvants that may enhance the potency and durability of vaccine-induced immunity.(3) To define correlates of vaccine-mediated protection and to transfer technology to establish in vitro alternatives to live challenge as a means of assuring vaccine strain potency to labs in developing countries.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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