Award details

Towards improved vaccines for control of avian pathogenic Escherichia coli in poultry

Reference	BBS/E/I/00001461
Principal Investigator / Supervisor	Dr Francis Dziva
Co-Investigators / Co-Supervisors	Professor Peter Kaiser, Professor Mark Stevens
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	204,633
Status	Completed
Type	Institute Project
Start date	18/01/2010
End date	17/07/2012
Duration	30 months

Abstract

Avian pathogenic Escherichia coli (APEC) cause colibacillosis in poultry and pose a significant threat to food security and animal welfare worldwide. Existing vaccines confer limited serotype-specific protection and the immunological basis of resistance is not defined. We propose to dissect protective immune responses induced by primary infection or vaccination in turkeys toward the rational design of improved control strategies. This will be achieved via the following objectives: 1. Define immune responses of turkeys to existing live-attenuated and killed APEC vaccines. 2. Define immune responses of turkeys to primary and secondary APEC infection. 3. Evaluate the role of B cells in vaccine-mediated protection and clearance of APEC. 4. Evaluate the impact of Th-biasing adjuvants on vaccine-induced protective responses.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Animal Welfare, Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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