Award details

Initiation and maintenance of vector arthropod colonies, elucidation of vector-virus interactions and the inheritance of competence and refractoriness

Reference	BBS/E/I/00001445
Principal Investigator / Supervisor	Dr Simon Carpenter
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	771,374
Status	Completed
Type	Institute Project
Start date	01/07/2009
End date	31/03/2012
Duration	33 months

Abstract

Unique colonies of several species of arthropod vectors are already maintained, with facilities available to expand into new arthropod groups or species as appropriate scientific opportunities arise. The current Culicoides colonies are vectors of important notifiable viruses including bluetongue virus and African horse sickness virus. The tick colonies are vectors of African swine fever virus. These resources enable the continuous provision of large numbers of individual vectors of known physiological state, thereby facilitating year-round research on the infection, replication and transmission of the study viruses by the vectors, and all aspects of virus-vector interactions. Also, the production by selective breeding of daughter colonies of individual vector species, each with a defined rate of oral susceptibility and transmission, and the sequencing of the genomes of individuals from such colonies, will provide unrivalled tools to investigate the inheritance and the genetic basis of susceptibility and refractoriness. These unique resources provide outstanding opportunities to promote multidisciplinary investigations (molecular, entomological, virological, genetic, modelling) and collaborations (both within and beyond IAH), and also facilitate training of colleagues at a range of levels from student to post-doctoral fellow.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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